Resveratrol

Resveratrol is a member of a group of plant compounds called polyphenols. These compounds are thought to have antioxidant properties, protecting the body against the kind of damage linked to increased risk for conditions such as cancer and heart disease.[1][2][3] Resveratrol is found in the skin of red grapes, but other sources include nuts and berries. Our unique formula contains a high-grade resveratrol extract from the Japanese knotweed plant Polygonum cuspidatum. Early research, mostly done in test tubes and in animals, suggests that resveratrol might help protect the body against a number of diseases, [2][4][5] including:

Heart disease. Resveratrol helps reduce inflammation, prevents the oxidation of LDL "bad" cholesterol, and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack.

Cancer. Resveratrol is thought to limit the spread of cancer cells and trigger the process of cancer cell death (apoptosis).

Alzheimer's disease. Resveratrol may protect nerve cells from damage and the buildup of plaque that can lead to Alzheimer's.

Diabetes. Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the effects of the blood sugar-lowering hormone, insulin. Insulin resistance is a precursor to diabetes.

Resveratrol has been shown to activate a family of enzymes called sirtuins.[6] Studies over the last few years have found that resveratrol can extend lifespan in yeast, worms, flies, and fish. Rodent studies suggest that resveratrol might even help against some of the effects of an unhealthy lifestyle and lead to increased longevity.[1][2][7] The compound mimics the effects of calorie restriction in reducing oxidative stress on cells and organs. Resveratrol-treated mice fed a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by mimicking the effects of caloric restriction.

Resveratrol has also been linked to prevention of age-related problems such as heart disease and insulin resistance. Researchers believe that resveratrol activates the SIRT1 gene, a biological mechanism that seems to protect the body against the harmful effects of obesity and the diseases of aging.[8]

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, or cure any disease. The information provided above comes in part from WebMD.

References

1. Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., ... & Sinclair, D. A. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342.

2. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., ... & Auwerx, J. (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell, 127(6), 1209-1122.

3. Hung, L. M., Chen, J. K., Huang, S. S., Lee, R. S., & Su, M. J. (2000). Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular research, 47(3), 549-555.

4. Ray, P. S., Maulik, G., Cordis, G. A., Bertelli, A. A., Bertelli, A., & Das, D. K. (1999). The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radical Biology and Medicine, 27(1), 160-169.

5. Markus, M. A., & Morris, B. J. (2008). Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical interventions in aging, 3(2), 331.

6. Um, J. H., Park, S. J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., ... & Chung, J. H. (2020). AMP-activated protein kinase–deficient mice are resistant to the metabolic effects of resveratrol. Diabetes, 59(3), 554-563.

7. Thirunavukkarasu, M., Penumathsa, S. V., Koneru, S., Juhasz, B., Zhan, L., Otani, H., ... & Maulik, N. (2007). Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radical Biology and Medicine, 43(5), 720-729.

8. Szkudelska, K., & Szkudelski, T. (2020). Resveratrol, obesity and diabetes. European journal of pharmacology, 635(1), 1-8.